From a certain point of view, Loki's importance to the Marvel Cinematic Universe cannot be overstated. Without this story, the Multiverse Saga has no multiverse. Surprisingly, besides references to Loki's past, the series doesn't feature many MCU crossover elements. Nonetheless, most aspects of the series can trace their roots in the Marvel Comics universe, including Hunter X-5's Brad Wolfe alias and his movie Zaniac.
Source:https://www.cbr.com/loki-hunter-x5-brad-wolfe-zaniac-marvel-comics/