Fans of Star Trek: Voyager likely recognize the reference to perhaps the most infamous episode in the title of Lower Decks' Season 4 premiere. The 24th episode of Voyager Season 2 was called "Tuvix," a portmanteau of "Tuvok" and "Neelix." Even 28 years after the episode debuted, fans still debate the moral dilemma posed by the episode, but Lower Decks just simplified it. The show may be an animated comedy, but it is still Star Trek, after all.
Source：https://www.cbr.com/star-trek-lower-decks-voyager-biggest-moral-dilemma/
