New York City houses the majority of Marvel's superheroes, operating as the hub of the Avengers, X-Men, and Defenders. Nearly every Spider-Man game takes place in the sprawling city, and many comic events use the city as their backdrop. Some of Spider-Man's best comics actively involve New York's heroes or the whole city itself.
Source:https://www.cbr.com/spiderman-best-comic-events-featuring-new-york-ranked/