DC Comics has built up an impressive universe full of creative, colorful, and interesting heroes and villains. In fact, the company's collection of villains is arguably even more compelling than Marvel's, and DC perfected many of the classic supervillain tropes first. However, many readers remain uncertain as to who exactly was the first in the long line of supervillains.
Source:https://www.cbr.com/first-supervillain-dc-comics-ultra-humanite/